Despite this overwhelming heterogeneity, neoantigens arising from mutations in OGT, TGFBR2, CASP5, BAX, ASTE1, ACVR2, TAF1B, PTEN are considered to be common as they have been shown to be present in >50% of MSI-H tumours [52,72]. This evidence concerns the gene ACVR2A and neoplasm.