IGHE and helminthiasis: Several factors, sometimes acting concomitantly, modulate the IgE primary response and sensitization process, including the levels of allergen exposure (which in turn depends on protein production by the source, permanence in the house dust and the air, effects of other enzymes upon the allergen), the persistence of exposure, age of exposed individuals, boosting of the IgE responses by conditions such as air pollution or helminth infections, and stimulation of Th1 responses by bacterial and other products [5,6,7,8,9].