The detailed analysis of this statistic method we show in Supplementary Table S2 We can observe that 52% of AD patients reached a positive level of specific IgE to these molecular components: Fel d 7 (lipocalin, cat) Art v (mugwort), Bla g 9 (arginine kinase, German cockroach), Cyn d (Bermuda grass) and Can f 4 (lipocalin, dog). The gene discussed is IGHE; the disease is Alzheimer disease.