Girard et al. demonstrated that MITFlow/AXLhigh melanoma cells resistant to BRAF inhibitors (BRAFi) exhibit a CAF-like phenotype due to their acquired ability to deposit a fibrillar ECM network, composed of collagen fibers, collagen cross-linking enzymes, fibronectin, tenascin C, and thrombospondin 1 [109]. The gene discussed is TNC; the disease is melanoma.