Therefore, it is possible to assume that the anti-tumor role exerted by dermal fibroblasts could be associated with their ability to produce anti-tumor proteins (Figure 1), such as transforming growth factor-beta (TGF-β), which can act as a tumor suppressor at the early stages of carcinogenesis [22,95], whey acidic protein four-disulfide core domain 1 (WFDC1) [96] and several cytokines, such as interferon-gamma (IFNγ), tumor necrosis factor-alpha (TNF-α) and IL-15, which are involved in immune cell mobilization [97,98]. This evidence concerns the gene WFDC1 and neoplasm.