Melanoma melanosomal miR-211 affects the expression of insulin-like growth factor 2 receptor (IGF2R), upregulate MAPK signalling pathway, which results in increased fibroblast proliferation, migration, and over-production of proinflammatory proteins, including IL-1β, IL-6, IL-8, CXCL1, CXCL2, and cyclooxygenase 2 (COX-2) [53]. This evidence concerns the gene IL1B and melanoma.