TGFB1 and neoplasm: Consequently, Ngwani’s study suggests that the pharmacological inhibition of PDGF-BB and TGF-β, and the use of PEDF small peptide mimetics could be novel and promising therapeutic approaches to restore the in vivo expression of PEDF in fibroblasts and the tumor milieu and restrain or reverse fibroblast activation thus impeding CAF transformation [122].