Based on the result showing that BALF M1 macrophages expressed a significantly higher level of CX3CR1 than BALF M2 macrophages in SKG-ILD, we speculated that anti-CX3CL1 mAb efficiently suppressed the migration of M1 macrophages, but not M2 macrophages. This evidence concerns the gene CX3CR1 and interstitial lung disease.