These signaling pathways showed that, after LPS infection, several DEGs were mainly related to immune function, such as up-regulated expression of CCL5, IL8, NFKBIA, TRAF3, and TNFAIP3, and down-regulated expression of MEF2C, MAP2K6, TLR1, TLR2, and IRF5. Here, TLR2 is linked to van der Woude syndrome.