PANX1 and Infertility: According to new data (https://www.omim.org/entry/608420, accessed date 15 May 2021), five variants of PANX1 are clinically significant: Gln392Ter, Cys347Ser, Lys346Glu, and 9-BP DEL, NT61 lead to human oocyte development defects and infertility [28,29].