Nonetheless, since increased GluN2B serine(1303) phosphorylation was detected in human perigliomal tissue [92], and given that PER is quite effective in suppressing glioma-associated seizures (Table 1) [93,94,95,96,97,98], whether the efficacy of PER in brain tumors could partially rely on PTEN-mediated reversal of upregulated GluN2B tyrosine(1472) phosphorylation is an attractive hypothesis. This evidence concerns the gene GRIN2B and central nervous system cancer.