Nuclear factor erythroid 2-related factor 2 (Nrf2) is a translational activating protein that translocates to the nucleus in response to oxidative stress, resulting in increased expression of numerous cytoprotective genes, including genes coding for mitochondrial and non-mitochondrial antioxidant proteins, and has been shown to play a critical role in the pathogenesis of schizophrenia [37,38]. The gene discussed is NFE2L2; the disease is schizophrenia.