For instance, mGluR5 agonist—VU0409551, produced rapid antipsychotic-like and cognition-enhancing activity in rodent models of schizophrenia and turned out to be effective in reversing the deficits in serine racemase knockout mice, a model that mimics many behavioral and neurochemical abnormalities observed in this disease [184]. The gene discussed is GRM5; the disease is schizophrenia.