Neutrophils arrested on LSEC in liver sinusoids increased tumor cell adhesion by interaction of CD11b/CD18 (Mac-1) on neutrophils and ICAM on tumor cells, acting as a bridge between disseminating tumor cells and liver parenchyma [80] (Figure 2, in sinusoid/space of disse/parenchyma). The gene discussed is ITGAM; the disease is neoplasm.