In a mouse CRC liver metastasis model, loss of Ndrg2 (N-myc downstream-regulated gene 2) gene in macrophage shifted TAM polarization to M1 phenotype and thus alleviated CRC liver metastasis [86] (Figure 2, in sinusoid/space of disse/parenchyma). This evidence concerns the gene NDRG2 and colorectal carcinoma.