Additionally, lysyl oxidase-like 4 (LOXL4) protein was demonstrated to be upregulated in neutrophils in CRC liver metastases with replacement HGP compared to desmoplastic type of liver metastases and the adjacent normal liver, which was associated with resistance to neoadjuvant anti-angiogenic therapy [76]. The gene discussed is LOXL4; the disease is colorectal carcinoma.