ALOX5 and rheumatoid arthritis: Our study reveals 5-LOX as a direct target of TWG by using cell-free assays and inhibition of 5-LOX products in M1-MDM and in PMNL; 5-LOX and its products, especially LTB4, have been implicated in RA as well [6,11], playing essential roles in the induction of pain and bone damage [38].