We found TERT to be highly immunogenic, and, in the case of ectopic expression, capable of limiting the growth and metastatic activity of murine adenocarcinoma cells [35], and attributed these properties to the capacity of TERT to generate short RNAs and telomeric DNA/RNA hybrids [70,71,72] that mediate innate immune signaling [70,71,73], including the induction of type I IFNs. This evidence concerns the gene TERT and adenocarcinoma.