Moreover, a nucleotide-binding oligomerization domain-like receptor (NLR) protein is the main component of inflammasomes and is classified into four types: NLRP1/NALP1b inflammasome [60], NLRC4/IPAF inflammasome [61,62], NLRP3/NALP3 inflammasome [63], and AIM2 (absent in melanoma 2) containing inflammasome [64]. This evidence concerns the gene NLRP3 and melanoma.