EMP3 and urinary bladder cancer: Conversely, Wang et al. have reported that EMP3 overexpression in TSGH8301 human bladder cancer cells increased p-Akt levels [36]; however, in contrast to the previous study [35], there was a concomitant upregulation of the p110α catalytic subunit of PI3K and no reported effect on the p85 subunit [36].