IGF1R and glioblastoma: Other RTKs activated in IDH-wt GBM include PDGFRA (amplified in 10–13% cases), the hepatocyte growth factor receptor MET (amplified in 4% of cases), the EGFR family member ErbB2/HER2 (mutated in 8% of cases), the insulin-like growth factor 1 receptor (IGF-1R), and members of the vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) families [4,15].