Recently, topical rapamycin and delphinidin, a dietary antioxidant found abundantly in pigmented fruits and vegetables as therapeutic agents of psoriasis have been identified to alleviate psoriatic lesions in the imiquimod (IMQ)-induced psoriasis phenotype in mice via suppressing the PI3K/Akt/mTOR pathway [117,118,119]. This evidence concerns the gene AKT1 and psoriasis.