Interestingly, in NSCLC, the levels of HO-1 correlates with advanced stage (III-IV), T3, and T4 status and with lymph node metastasis; however, no association with overall survival has been demonstrated when patients were divided into two different subgroups related to HO-1 intensity of expression. Here, HMOX1 is linked to metastatic malignant neoplasm in the lymph nodes.