Furthermore, we have recently demonstrated in BRAFv600 melanoma cells that HO-1 inhibition with tin mesoporphyrin IX (SnMPIX) and HO-1 siRNAdown-regulation favors cell death induced by vemurafenib, and increases NK cancer cell recognition by up-regulating B7H6 and ULBP3 ligands of NK cells [140]. The gene discussed is HMOX1; the disease is melanoma.