In addition, Ginnalin A, a polyphenolic compound isolated from red maple (Acer rubrum), inhibits cell viability and colony formation in colorectal cancer, inducing cell cycle arrest by activating the Nrf2/HO-1 pathway through the up-regulation of p62 and the inhibition of Keap1 [228]. The gene discussed is HMOX1; the disease is colorectal cancer.