HMOX1 and metastatic malignant neoplasm in the lymph nodes: Further, high levels of HO-1 in infiltrating macrophages show a positive correlation with vascular density and high tumor grade in glioblastoma [178], with stage II, lymph node metastasis, and poor prognosis in colorectal cancer [179], and with a high Gleason score and bone metastasis in prostate cancer [117].