p38 MAPK is responsible for Nrf2-dependent HO-1 activation in human MCF-7 breast cancer cells exposed to cadmium chloride [73] and cooperates with ERK for Nrf2-independent HO-1 activation in MKN-45 and in MKN-28 human gastric cancer cells [74]. The gene discussed is HMOX1; the disease is gastric cancer.