Moreover, it has been demonstrated that the acetylation of the truncated form of HO-1 significantly enhances JunD-mediated AP-1 transcriptional activity leading to cancer cell proliferation, invasion, and resistance to therapy [91], indicating that post-translational modification of nuclear HO-1 plays an important role in cell proliferation, migration, and metastasis [92]. Here, HMOX1 is linked to cancer.