Since breast cancers have elevated polyamines and are more dependent on spermidine for proliferation, therefore, another approach to targeting polyamine biology in breast cancer treatment could be to inhibit the link between spermidine and eIF5A by inhibiting the enzymes (deoxyhypusine synthase and deoxyhypusine hydroxylase) that catalyze the hypusination reaction. The gene discussed is DOHH; the disease is breast cancer.