Following the methods described, we found that 21 genes (TNF, MAPK1, MAPK8, PIK3CA, PIK3CB, PIK3CD, MAPK3, INSR, HK3, HK2, PKM, INS, MTOR, PIK3CG, ADIPOQ, PIK3R1, PIK3R2, PIK3R3, MAPK10, MAPK9, and IKBKB) are shared by both diabetes and COVID-19, of which seven genes (TNF, MAPK1, MAPK8, PIK3CA. PIK3CB, PIK3CD, and MAPK3) are the core gene set that is shared among all three groups of datasets (Supplementary Figure S1A). The gene discussed is IKBKB; the disease is diabetes mellitus.