The top five targets identified based on candidate gene prioritization were C3, CFB, EGFR, IL6, and TLR2 (Table 1 and Supplementary Table S5 and Supplementary Figure S5C), where the 39 common core genes were used as a test set, and 1899 genes from the COVID-19 pathway (KEGG) and our multi-omics datasets were used as training sets. The gene discussed is C3; the disease is COVID-19.