Here, IgG is the predominant class, and the intensely inflammatory nature of IgG induces severe COVID-19 infection through inflammation, complement activation, and induction of phagocytosis by, e.g., macrophages, neutrophils, and the activation of the cellular immune response, including CD4+ and cytotoxic CD8+ T cells that cannot, by their nature, prevent infection. This evidence concerns the gene CD8A and infection.