However, the change in GAD score between inclusion and the end of the study period was dependent on sex (p = 0.0075), ELA (p = 0.061), ATE cluster (p = 0.062), age (p = 0.070), and pre-existing rheumatic disease (p = 0.073; Supplementary Table S4; Figure 5F). The gene discussed is GAD1; the disease is rheumatic disorder.