MAPT and Alzheimer disease: AD neuropathological damage is characterized by extracellular deposits of the beta-amyloid (Aβ) peptide, the formation of intracellular neurofibrillary tangles of hyperphosphorylated tau protein (p-Tau), and the impairment of neurons and synaptic connections in the cerebral cortex and hippocampus, a key brain region involved in learning and memory processes and emotional control [1,13,14,15].