NPPB and stroke disorder: In a Cox regression model, upward changes in log2-transformed NT-proBNP were associated with increased risk of stroke or systemic embolic events in anticoagulated patients (adjusted hazard ratio (adj-HR) 1.74; 95% confidence interval (CI) 1.36–2.23 and adj-HR 1.27; 95% CI 1.07–1.50, respectively) [27].