In a prospective multicenter cohort study that quantified MR-proANP levels in ischemic stroke patients within 24 h of stroke onset, the diagnosis of AF at hospital discharge were associated with MR-proANP with an OR of 18.35 (95% CI 7.94–42.45, p < 0.001) [29]. The gene discussed is NPPA; the disease is ischemic stroke.