The initial status of virus-specific CD4+ T cell differentiation appears to play an important role in the pathogenesis of disease, because adoptive transfer of VP2-primed VP2-TCR-Tg CD4+ T cells into naive SJL mice, in contrast to the naïve T cells, provides protection from TMEV-induced demyelinating disease [136]. The gene discussed is CD4; the disease is demyelinating disease.