IL7 and acute lymphoblastic leukemia: In the in vitro culture of T-ALL cells, the inhibition of complex I of the respiratory chain with rotenone and the disassembly of NADPH subunits with apocynin both abrogated the IL-7-mediated elevation of intracellular ROS levels, confirming that the mitochondrial respiratory chain and NOX are also the main sources of intracellular ROS production in T-ALL cells [84].