Lim et al. found that ROS induced by IL-7 in the downstream JAK/STAT pathway positively increased JAK/STAT signaling and that the occurrence of B-ALL and the survival of B-ALL cells were dependent on high levels of ROS driven by IL-7-dependent JAK/STAT signaling [66]. The gene discussed is SOAT1; the disease is precursor B-cell acute lymphoblastic leukemia.