This so-called “fibrous body” that occupies much of the tumor cell cytoplasm, trapping the few secretory granules and other organelles, is decorated by CAM 5.2, AE1/AE3 and CK18 antibodies [17] and represents the hallmark of this tumor type, being present in well over 70% of tumor cells. The gene discussed is SLC4A3; the disease is neoplasm.