PRNP and prion disease: The probing endogenous PrPC expression at the transcript and protein levels in different animal models and serum or plasma samples from a human cohort all concluded that PrPC reports statistically significant differential expressions in kidney tissues for renal and prion diseases, yet the direction of changes in the PrPC expressions diverged, as the reported data alternated between overexpression and downregulation, depending on the model and experimental conditions.