CCDC25 and cholangiocarcinoma: However, a significant correlation was observed between KLK11 and CCDC25 expressions in CCA with lymph node metastasis (p = 0.028 and r = 0.593) (Figure 4B), but not in CCA without lymph node metastasis (p = 0.417 and r = 0.600) (Figure 4C).