Interestingly, the ectopic expression of STAT3 in HEK293T did not significantly increase XRCC1 protein content (1.03 ± 0.035), indicating that STAT3 has a less significant role in regulating XRCC1 expression in HEK293T and occurs through a cancer-related, possibly TNBC-specific, mechanism. The gene discussed is XRCC1; the disease is cancer.