Here, we demonstrated that activation of STAT3 through cytokine stimulation or ectopic overexpression stimulated the expression of XRCC1. Further, we confirmed a binding site for STAT3 within the XRCC1 promoter with higher occupancy in triple negative breast cancer cell lines than in the nontumorigenic HEK293T. This evidence concerns the gene STAT3 and triple-negative breast carcinoma.