Among analyzed human cancers, MARCH8 was significantly downregulated in 10 additional tumor types when compared to the respective normal tissues, including bladder, cervical, colon, kidney, lung, rectum, thyroid, and uterine (Figure 1B); on the other hand, upregulated MARCH8 expression was observed in cholangial tumors, and no significant changes were found in stomach and other tumors (Figure 1B). The gene discussed is MARCHF8; the disease is cancer.