MTOR and non-small cell lung carcinoma: Consistently, overexpression of MARCH8 has been shown to inhibit non-small-cell lung cancer (NSCLC) cell proliferation and metastasis via the phosphoinositide 3-kinase and mTOR signaling pathways and induced apoptosis of A549 and H1299 cells [29], demonstrating the antitumor properties of MARCH8 in NSCLC.