HHT was reported to induce the decreased synthesis of short-life proteins that are related to proliferation and apoptosis (e.g., c-Myc, Mcl-1, cyclin D1, β-catenin, Bcl-Abl, etc.), and has been used in clinical trials of AML for decades [42]. The gene discussed is CCND1; the disease is acute myeloid leukemia.