Therefore, anti-mesothelioma effects of the treatment should most likely be attributed to its impact on the innate immune cells, suggestive of reversal of the immunosuppressive skewing of tumor innate immune environment: reduced TAM and MDSC tumor infiltration and CSF1R-expressing TAM proliferation, M1 polarization of the remaining TAMs and DC activation. The gene discussed is CSF1R; the disease is neoplasm.