Colony-Stimulating Factor 1 (CSF1)/Colony-Stimulating Factor Receptor (CSF1R) signaling plays important role in the recruitment of monocytes into mesothelioma tumors, their differentiation into M2-like macrophages [11,12], impaired CD8 T cell cytotoxicity [12] and chemoresistance [11,13]. The gene discussed is CSF1R; the disease is mesothelioma.