Apart from the effects on mature F4/80 macrophages, CSF1Ri significantly limited the number of tumor-promoting Myeloid-Derived Suppressor Cells (MDSCs) (known to express CSF1R, 22): both Mo-MDSCs (CD11b+/Ly6C+, Figure 2G) and PMN-MDSCs (CD11b+/Ly6G+, Figure 2H) subpopulations were significantly reduced upon CSF1Ri administration. The gene discussed is CSF1R; the disease is neoplasm.