TQ (intra-articularly injection of 0.3 mL; 10 mmol/L) also upregulated the expression of MMP-1 (matrix metalloproteinase-1) (tissue inhibitors) and downregulated MMP-13 in both rabbit chondrocytes and animal models of osteoarthritis induced by anterior cruciate ligament transaction [41]. This evidence concerns the gene MMP1 and osteoarthritis.