STK11 and diabetes mellitus: Figure 1 summarizes the anticancer molecular mechanisms of metformin on cervical cancer cell. With regards to the action of metformin in diabetes, it was revealed that metformin activates AMPK, which leads to targeting of rapamycin complex 2 (TORC2) phosphorylation and results in the blocking of translocation and transcription of genes related to gluconeogenesis [35]. LKB1 exerts an effect that is biochemically sufficient to activate AMPK [35].