We observed no significant differences between patients who were concordant, upgraded, or downgraded in terms of PSA, PSA density, previous biopsy, lesion location, dimension of lesion, PIRADS score, number of targeted biopsy cores, maximum cancer core length (MCCL), and percentage of positive biopsy cores (PBC) out of total/targeted/systematic cores (Table 3). Here, KLK3 is linked to cancer.