STAT3 and familial pancreatic carcinoma: Unexpectedly, compound 4 appears to be a strong dual inhibitor of JAK/signal transducer and activator of transcription 3 (STAT3) and Src family of protein tyrosine kinases (SFKs)/STAT3 signaling that is associated with the induction of apoptosis in human pancreatic cancer cells [47,139].