STAT3 and chronic myelogenous leukemia, BCR-ABL1 positive: Likewise, compound 3, which contains a dihydroxypropyl 3′-oxime substituent together with an OCH3 group, is a potent inhibitor of Src kinase, and it downregulated the constitutively activated signal transducer and activator of transcription 3 (STAT3) or STAT5 in human breast cancer CML cells [46].