In addition, MM-MSCs showed an early senescence state with increased cell size and accumulation of cells in S phase, and a characteristic senescence-associated secretory profile (higher expression of HGF, IGF-2, IL-6, IL-8, MCP-1, MIP-1a, DKK1, and VEGF in MM-MSCs) [26]. This evidence concerns the gene IL6 and Miyoshi myopathy.