Additionally, MM-MSC transcriptional signature was found enriched in functions related to MM pathogenesis, such as IL-17 pathway and TNF signaling via NF-κB, osteoblastogenesis inhibition, MSC proliferation, immune-suppressive potential, and a reinforced pro-adipogenous phenotype (upregulation of Peroxisome Proliferator-Activated Receptor (PPAR) signaling and genes for cholesterol efflux and lipid metabolism). Here, TNF is linked to Miyoshi myopathy.