Studies from Adamik et al. showed that interaction of MM cells with MSCs induced the binding of the transcriptional repressor Gfi1 (growth factor independence-1) to the Runx2 promoter together with the chromatin modifier Enhancer of Zeste homolog 2 (EZH2), histone deacetylase 1 (HDAC1), and Lysine-specific demethylase 1 (LSD1) [20,59]. Here, HDAC1 is linked to Miyoshi myopathy.