In this sense, myeloma to MSC interactions through adhesion molecules are prominent: VLA-4 (Very Late Antigen 4; α4β1) to VCAM (Vascular Adhesion Molecule); LFA-1 (Leukocyte Function associated Antigen 1) and MUC-1 (Mucin 1, cell surface-associated) to ICAM (Intercellular Adhesion Molecule); AXIIR (Annexin II Receptor) to AXII (Annexin II); Notch1/2 and Jagged1/2 to Jagged1/Dll (Delta-like) and Notch 1 [5,19,20,21]. Here, NOTCH1 is linked to plasma cell myeloma.