MM cells also produce IL6, soluble RANKL, and many other so-called “OC-activating factors” (e.g., CCL3, IL3, IL7, IL8, IL1β, HGF, CCL20), which have been reported to enhance OC formation from myeloid precursors and OC resorption, and which are out of the scope of this review. This evidence concerns the gene CCL3 and Miyoshi myopathy.