TNF and psoriasis: While cyclosporine has no known interaction with alcohol and targeted therapies are a safe choice not only to achieve a specific and preferred therapeutic response but also in patients with impaired liver functions—the very rare cases of autoimmune hepatitis observed in patients receiving TNFα inhibitor treatments is not related to alcohol consumption [83]—prescribing acitretin and methotrexate needs special attention in psoriasis patients with alcohol problems.