GNRH1 and prostate neoplasm: On the other hand, in our laboratory, we could observe the presence of one single class of low affinity GnRH-binding sites in PCa cells, both androgen-dependent and castration-resistant [139,155], while the presence of a single class of high affinity GnRH-binding sites was reported in PC3 CRPC cells and in Dunning R3327 prostatic tumor tissue [156,157].