GNRH1 and posterior cortical atrophy: In line with these observations, cleaved caspase-8 and -3, but not -9, and increased expression and phosphorylation of p53, were reported to increase in primary cell cultures from human PCa samples, supporting the idea that the extrinsic (but not intrinsic) apoptosis pathway is involved in the antitumor activity of GnRH agonists [171,173,180,181].