GNRH1 and posterior cortical atrophy: We demonstrated that, in PCa and, specifically, CRPC cells, GnRH-R activation significantly interferes with the forskolin-induced increase in cytoplasmic cAMP levels while pertussis toxin counteracts the antiproliferative effects of GnRH analogs [152], suggesting that the Gαi signaling pathway is involved in the anticancer activity of these compounds.