GNRHR and posterior cortical atrophy: At the molecular level, we demonstrated that a GnRH-R, with the same mRNA and protein size with the gonadotrope receptors, is expressed in human androgen-dependent and CRPC cells [21,137,158,159]; these observations were further confirmed by studies performed in rat Dunning R3327 prostatic adenocarcinoma and in human PCa cells and tissue biopsies [160,161,162,163].