NFE2L2 and malignant colon neoplasm: Allicin has also been shown to induce the nuclear translocation and promoter-binding activity of Nrf2 and knockdown of Nrf2 abrogated allicin-induced apoptosis in HCT-116 cells, demonstrating that Nrf2 mediates allicin-induced apoptotic death of colon cancer cells [146].