Other studies reported that luteolin inhibits methylation of the Nrf2 promoter region in colon cancer HT-29 and SNU-407 cells, thereby increasing apoptosis-related proteins and antioxidant enzymes such as GCLC, glutathione synthetase (GSS), catalase, and HO-1 [143]. This evidence concerns the gene NFE2L2 and colonic neoplasm.