In a dimethylhydrazine-induced colon cancer model in Wistar rats, genistein treatment (2.5 mg/kg body weight) for 6 weeks increased Nrf2 and HO-1 protein expression and maintained the levels of the antioxidant enzymes glutathione and NADPH at the same level as that of normal mice [156]. This evidence concerns the gene NFE2L2 and malignant colon neoplasm.