Loss of function variants in the potassium voltage-gated channel subfamily D member 3 (KCND3/KV4.3) have been originally associated with spinocerebellar ataxia SCA19/22 (OMIM# 607346), a rare inherited neurodegenerative disorder characterized by slowly progressive ataxia, and a variable occurrence of cognitive impairment, signs of frontal lobe dysfunction, postural head tremor, seizures, pyramidal signs and neuropathy [1,2]. Here, KCND3 is linked to Cognitive impairment.