While the latter results in a clinical phenotype similar to that of HFE hemochromatosis, a more distinct clinical picture is seen in ferroportin disease, with iron retention mainly being localized to the macrophages of the spleen, liver, and spine, with marginal delivery of iron to circulating transferrin, resulting in a normal or low transferrin saturation (Figure 4). This evidence concerns the gene TF and hemochromatosis type 1.