Male HFE hemochromatosis patients with ferritin >300 μg/L and transferrin saturation >50%, and female patients with ferritin >200 μg/L and transferrin saturation >45%, should undergo weekly or biweekly phlebotomy, removing a blood volume of 400–500 mL, equivalent to 200–250 mg of iron, each session. This evidence concerns the gene TF and hemochromatosis type 1.