Furthermore, in another study, Galvan et al. generated a knock-in mouse in which S600 of Drp1 was mutated to alanine (Drp1S600A) and showed that Drp S600A transgenic mice with db/db background exhibited decreased progression of diabetic nephropathy, decreased mitochondrial ROS production, and mitochondrial fragmentation in kidney tissues [60]. The gene discussed is DNM1L; the disease is diabetic kidney disease.