Not least among these capabilities is the inhibition of the processes of invasion, migration, angiogenesis, and treatment resistance through the modulation of critical signaling pathways in glial cells, such as VEGFA, ERK1/2 and STAT3.Therefore, the anti-tumor effect of prelatent AT should be explored in the treatment of GB where prognosis is poor given the limited efficacy of conventional therapy. This evidence concerns the gene MAPK3 and neoplasm.