Since IGF2 has been shown to play an important role in cancer progression by limiting therapy efficacy (reviewed in Reference [44]) and has also been shown to be associated with FOXO3 activity in mesenchymal progenitor cells [45], we utilized the TCGA RNAseq data of HNC patients to explore whether expression of FOXO family members is associated with IGF2 expression. This evidence concerns the gene FOXO3 and cancer.