In Xiphophorus malignant melanoma tissue, oxidative stress increases and is correlated with upregulation of the antioxidative proteins, glutathione-S-transferase mu3 (GST mu3) and peroxiredoxin-6 (PRDX6), but not PRDX2, which was subject to a non-significant increase [111]. Here, PRDX6 is linked to melanoma.