AKT1 and melanoma: In some human melanoma cell lines, EGFR signaling acts through the cytoskeletal protein, filamin A (FLNa), a regulator of the PKB/Akt and ERK1/2 pathways, and is associated with migration of the integrin, α1β1, to focal adhesions where it promotes cell adhesion and migration through contact with collagen type I [110].