HSD11B1 and hepatocellular carcinoma: Adrenosterone is an inhibitor of hydroxysteroid (11-beta) dehydrogenase 1, which is highly expressed in metastatic HCC, rabeprazole acts to block hydrogen/potassium-transporting ATPase, and olmesartan prevents the action of angiotensin 2 types 1 receptor, which promotes metastasis progression [150].