Unlike miR-17, 18a, 182, 210, and 214, whose increased expression promotes melanoma, upregulation of miR-126 in human cells has anti-melanoma function through its modulation of v-crk sarcoma virus CT10 oncogene homolog (CRK), a regulator of migration and adhesion [126,127] (Figure 1). Here, CRK is linked to melanoma.