BCL2 and melanoma: A human A375 cell line melanoma xenograft murine model has shown that deletion of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the pentose-phosphate pathway, upregulates the antiapoptosis proteins Bcl-2 and Bcl-xL, whereas the tumor suppressor, Fas, was shown to be downregulated [66].