AKT1 and melanoma: Recently, a human melanoma cell xenotransplant zebrafish model demonstrated that the lectin, BEL β-trefoil, prevented melanoma migration and reduced expression of Runx2, a gene upregulated and associated with melanoma invasion and migration, which acts to regulate the tumor suppressor p53 in pathways integrating Ras/MEK/ERK and PI3K/Akt signaling [159].