Inhibition of hydroxysteroid (11-beta) dehydrogenase1 (HSD11b1), a prognostic biomarker of human HCC, in crosses between the tamoxifen-controllable Twist1a-ERT2 and Xmrk transgenic HCC zebrafish, suppressed the metastasis of transplanted human cell lines and led to recovered E-cadherin expression via Snail and Slug transcription factor signaling [149,150]. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.