In human melanocytes, MAPK signaling causes reduction of MITF and increases ERBB3, FOXD3 and NRG1 transcription factor gene expression, with NRG1 and FOXD3 also further upregulating ERBB3, which can heterodimerize with EGFR causing melanoma metastasis [94,95,96]. This evidence concerns the gene NRG1 and melanoma.