For example, high expression of Caveolin-1 (CAV1), a membrane-associated scaffold protein, enhances the secretion of Interleukin-6 (IL-6) and IL-8 in CAFs and promotes PC invasion, while the down-regulation of CAV1 slows down the proliferation of PC cells [98]. The gene discussed is CXCL8; the disease is pachyonychia congenita.