CXCL10 and Decreased liver function: The current study demonstrating a predilection for higher IP10 in HCV-related hepatic inflammation and fibrosis (i.e., correlations with HCV viral load, FIB4, APRI, and other measures of liver dysfunction such as elevated AST, ALT, and GGT) replicates previous experiments [86,87], confirms reports that IP10 may be a useful biomarker of HCV and liver integrity [88,89,90], and suggests that HIV+HCV may result in significantly higher levels of IP10 than in either infection alone [91].