We first looked at an extended list of high-risk genes predisposing to melanoma (ACD, CDKN2A, CDK4, POT1, TERF2IP, and TERT) [56] or RCC (CDKN2B, FH, FLCN, MET, PBRM1, PTEN, SDHs, TSCs, and VHL) or both (BAP1 and MITF) [57]. The gene discussed is ACD; the disease is renal cell carcinoma.