Of note, PI3K/Akt affected cases tend to have a younger onset of both melanoma (median age of onset at 46 years old for cases with a rare deleterious variant in the PI3K/Akt pathway versus 53.5 years old without, p = 0.15) and RCC (48.5 vs. 55.5 years old, p = 0.07). The gene discussed is AKT1; the disease is renal cell carcinoma.