While it is unclear whether CCR5, its chemokine ligands or CXCL1 are the target of miR-378b, the determination of which genes are differentially expressed in the upper genital tract of infected miR-378b−/− mice will enable us to discover the genes that can be targeted in novel therapy to treat complications arising from Chlamydia infection. The gene discussed is CCR5; the disease is chlamydia infectious disease.