Furthermore, NLRP3 inflammasome releases proinflammatory cytokines (IL-1β, IL-18) and triggers gasdermin D-mediated pyroptotic cell death, as a result of which elevated level of enzyme lactate dehydrogenase (LDH) is observed in the blood of patients with COVID-19 and correlated with disease severity [78,84,85,86]. Here, IL1B is linked to COVID-19.