Finally, there is no clear consensus on whether or not the levels of sclerostin are altered in OI patients, although there is evidence of improved bone properties in several mouse models of OI (oim/oim [27], +/G610C, Brtl−/− [122], Col1a1+/Jrt [123], and Crtap−/− [124]) subjected to sclerostin inhibition. Here, COL1A1 is linked to osteogenesis imperfecta.