In addition, the expression of the receptors was regulated by IL1β in NHFs and NCFs, since the expression of both IL1R1 and IL1R2 increased after stimulation with IL1β, while receptors in tumor cells (SW480 and DLD1) were not affected by IL1β, probably due to the high basal levels of expression of the decoy receptor IL1R2 in those cancer cells (Figure 1H). Here, IL1R1 is linked to neoplasm.